DNA chips consist of an array of DNA probes (artificially synthesized DNA segments) immobilized on the surface of a glass or other substrate. When the DNA probes are allowed to react with sample DNA extracted from a specimen, researchers can simultaneously detect multiple types of DNA. Various DNA probes can be placed on a chip according to the purpose of the test, enabling the detection of DNA mutations which cause cancer or other diseases, DNA indicating differences in genetic make-up, and DNA of microbes that have invaded the body. DNA testing using DNA chips ensures dramatically faster diagnosis, holding promise for the realization of treatments optimized for each individual patient by accurately identifying types of diseases and stages of progression.

Example of a DNA Chip for Infectious Disease Diagnosis

Canon has developed an inkjet head specially designed for DNA chip fabrication that incorporates extremely small tanks to hold 1,000 varieties of DNA probes. Simultaneously printing 1,000 types of DNA probes makes it possible to fabricate highly reliable DNA chips accurately and in large quantities. In addition to ordinary analysis methods, Canon also led the world in developing a technology for visualizing DNA probes on glass substrates.

These technologies will enable stable supplies of high-quality chips suited to clinical applications. The company has already initiated development of a fully automatic DNA testing system that makes possible even faster and more accurate DNA testing.

Fully Automatic DNA Testing System